| Children |
| | 1. Samuel R. Cain, b. 30 Jun 1822, Gallia Co., OH d. 8 Apr 1898, Warren Co., IA (Age 75 years) |
| | 2. Emily Cain, b. 2 Apr 1824, Gallia Co., OH d. 16 Jan 1908, Clarke Co., IA (Age 83 years) |
| | 3. Clarissa Cain, b. 1 Dec 1826, Gallia Co., OH d. 23 Mar 1921, Beatrice, Gage Co., NE (Age 94 years) |
| | 4. James H. Cain, b. 26 Apr 1830, Gallia Co., OH d. 9 Aug 1914, Fairbury, Jefferson Co., NE (Age 84 years) |
| | 5. John Jefferson Cain, b. Feb 1831, Meigs Co., OH d. Yes, date unknown |
| | 6. Agnes Cain, b. 1832, Meigs Co., OH d. Yes, date unknown |
| | 7. Catherine Cain, b. 1833, Meigs Co., OH d. Yes, date unknown |
| | 8. Elizabeth Cain, b. 1835, Meigs Co., OH d. Yes, date unknown |
| | 9. Daniel Isaac Cain, b. 8 Jan 1836, Meigs Co., OH d. 19 Jul 1908, Osceola, Clarke Co., IA (Age 72 years) |
| | 10. David Cain, b. 1837, Meigs Co., OH d. Yes, date unknown |
| | 11. Edward Cain, b. 1838, Meigs Co., OH d. Yes, date unknown |
| | 12. William Henry Cain, b. 15 Oct 1845, Meigs Co., OH d. 28 Jul 1916, Carlisle, Warren Co., IA (Age 70 years) |
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